Morgan State University, Baltimore, MD
Porphyrins are compounds that promote chemical reactions in cells. This function allows porphyrins to be used in biomedical applications e.g. photodynamic therapy (PDT) for treating cancer. Porphyrins absorb light in cells containing a photosensitive drug designed to oxidize and kill malignant tissue. Metalloporphyrins are a type of porphyrins that serve specific functions that depend on the metal ion(s) in the molecule; e.g. heme metalloporphyrins deal with storage and transfer of oxygen in cells. Metalloporphyrins have properties that can be used in fluorescence mapping and imaging materials through spectroscopy. This study explores chemical derivatives of porphyrins, metal- organic frameworks (MOFs) containing tetrakis(4-carboxyphenyl)porphyrin (TCPP) and aluminum, Al-MOF-MeTCPP. The hypothesis is that absorption and emission of light by these MOFs can be predicted from TCPP spectra. It may be possible to modulate sorption and desorption (release) of drugs using light. Porphyrins absorb light within the wavelength range 500-600 nm which is observed as four vibronic Q peaks in absorption spectra, while metalloporphyrins have two Q bands peaks. Future research is to study high resolution synchronous fluorescence spectroscopy to observe electronic and vibronic transitions in TCPP, metalloporphyrins, and Al-MOF-MeTCPP and their use in drug development and delivery.